Translational fidelity in Escherichia coli: Contrasting role of neaA and ramA gene products in the ribosome functioning
L Topisirovic, R Villarroel, M De Wilde… - Molecular and General …, 1977 - Springer
L Topisirovic, R Villarroel, M De Wilde, A Herzog, T Cabezón, A Bollen
Molecular and General Genetics MGG, 1977•SpringerStrains carrying both the ram A1 and the nea A301 mutations do not exhibit the restriction of
informational suppressors normally associated with resistance to neamine. Furthermore,
ribosomes from such strains exhibit increased misreading in vitro with respect to particles
from the nea A strain. These properties suggest that translational fidelity may be
cooperatively controlled by ribosomal proteins S4 and S17, coded by ram A (rps D) and nea
A (rps Q) genes respectively.
informational suppressors normally associated with resistance to neamine. Furthermore,
ribosomes from such strains exhibit increased misreading in vitro with respect to particles
from the nea A strain. These properties suggest that translational fidelity may be
cooperatively controlled by ribosomal proteins S4 and S17, coded by ram A (rps D) and nea
A (rps Q) genes respectively.
Summary
Strains carrying both the ramA1 and the neaA301 mutations do not exhibit the restriction of informational suppressors normally associated with resistance to neamine. Furthermore, ribosomes from such strains exhibit increased misreading in vitro with respect to particles from the neaA strain. These properties suggest that translational fidelity may be cooperatively controlled by ribosomal proteins S4 and S17, coded by ramA (rpsD) and neaA (rpsQ) genes respectively.
Springer
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